Detroit at Houston 2:32 PM ET
Astros manager Joe Espada was pleased with Yordan Alvarez's contributions in Houston's 3-1 loss during Game 1 of the American League wild-card series against the Detroit Tigers on Tuesday.
Kansas City at Baltimore 4:38 PM ET
Zach Eflin began his season pitching in front of sparse crowds in St. Petersburg, Fla., for the Tampa Bay Rays.
NY Mets at Milwaukee 7:38 PM ET
The Milwaukee Brewers will turn to midseason acquisition Frankie Montas to stave off yet another postseason meltdown when they face the New York Mets on Wednesday in the second game of a National League wild-card series.
Atlanta at San Diego 8:38 PM ET
Max Fried was selected seventh overall by the San Diego Padres in the 2012 draft and was traded to Atlanta while he was a minor league prospect.