Seattle at Houston 2:10 PM ET
The Houston Astros can finally relax, at least for the next few days.
Chi. Cubs at Philadelphia 6:05 PM ET
The Philadelphia Phillies have won five straight games started by Cristopher Sanchez, and they hope to continue that streak on Wednesday when they wrap up their three-game home series with the Chicago Cubs.
Cincinnati at Cleveland 6:40 PM ET
Rookie Joey Cantillo could end up playing a vital role on the Cleveland Guardians' postseason pitching staff.
Tampa Bay at Detroit 6:40 PM ET
The streaking Detroit Tigers keep on marching toward an American League wild-card berth.
Milwaukee at Pittsburgh 6:40 PM ET
Willy Adames has added a new element to his game this season.
Kansas City at Washington 6:45 PM ET
A pair of anemic offenses will try to find some life when the Kansas Royals visit the Washington Nationals on Wednesday night.
Baltimore at NY Yankees 7:05 PM ET
While the Baltimore Orioles celebrated clinching a playoff spot on Tuesday, the New York Yankees were left waiting at least one more day to enjoy securing the American League East title.
Boston at Toronto 7:07 PM ET
Boston Red Sox right-hander Richard Fitts has yet to allow an earned run in his three-game major league career, something the host Toronto Blue Jays will aim to change on Wednesday night.
LA Angels at Chi. White Sox 7:40 PM ET
and keep a dubious, would-be major-league record on hold for now, too.
Miami at Minnesota 7:40 PM ET
Time is running out on the Minnesota Twins in their bid for a wild-card playoff berth.
St. Louis at Colorado 8:40 PM ET
The Colorado Rockies don't have a postseason on the horizon, but they do have motivation to finish strongly.
San Francisco at Arizona 9:40 PM ET
The San Francisco Giants have eight home runs over the first two games of their series with the Arizona Diamondbacks.
Texas at Oakland 9:40 PM ET
Having enjoyed the hors d'oeuvres of their three-day going-away party, the Oakland Athletics hope to serve the fans a perfectly cooked main course Wednesday night when they go for a second consecutive win over the Texas Rangers.
San Diego at LA Dodgers 10:10 PM ET
More drama awaits for the top two teams in the National League West when they meet Wednesday after the San Diego Padres took a wild 4-2 road victory over the Los Angeles Dodgers in the series opener.