St. Louis at Chi. Cubs 2:20 PM ET
Right-hander Erick Fedde makes his St. Louis debut on Friday afternoon as the visiting Cardinals try to bounce back from a walk-off loss to the Chicago Cubs in the series opener.
Kansas City at Detroit 6:40 PM ET
Tarik Skubal can finally pitch without the threat of being traded hanging over him.
Arizona at Pittsburgh 6:40 PM ET
The Arizona Diamondbacks would like to see their scintillating play in July carry over into August when they open a three-game series against the host Pittsburgh Pirates on Friday.
Milwaukee at Washington 6:45 PM ET
The Milwaukee Brewers hope a flip of the calendar will help turn their fortunes when they open a three-game series at the Washington Nationals on Friday night.
Toronto at NY Yankees 7:05 PM ET
Since walking into the visitors' dugout at Boston's Fenway Park on Sunday, Jazz Chisholm Jr. has created a memorable first impression for the New York Yankees.
Baltimore at Cleveland 7:10 PM ET
Jose Ramirez will look to continue his impressive power surge on Friday night when the Cleveland Guardians host the Baltimore Orioles in the second contest of a four-game series.
San Francisco at Cincinnati 7:10 PM ET
Two teams seeking consistency in a tight National League wild-card race open a key three-game weekend series on Friday night when the San Francisco Giants visit the Cincinnati Reds.
Miami at Atlanta 7:20 PM ET
The Atlanta Braves will turn to rookie Spencer Schwellenbach to continue their hot streak on Friday when they face the visiting Miami Marlins in the second game of their four-game series.
Boston at Texas 8:05 PM ET
Texas Rangers manager Bruce Bochy hasn't liked what he's seen from his team in its last two games, and he's undoubtedly hoping things look better when the Rangers open a three-game series against the visiting Boston Red Sox on Friday night in Arlington, Texas.
Tampa Bay at Houston 8:10 PM ET
Rafael Montero and Seth Martinez -- in advance of a 5-4 win over the Pittsburgh Pirates on Wednesday.
Chi. White Sox at Minnesota 8:10 PM ET
After spending much of July on the road, the Minnesota Twins are looking forward to spending the bulk of August at home.
NY Mets at LA Angels 9:38 PM ET
The Los Angeles Angels are once again concluding a disappointing season without three-time American League MVP Mike Trout on the field.
LA Dodgers at Oakland 9:40 PM ET
What appeared earlier like a break from a rugged schedule instead could prove to be a tough assignment for the Los Angeles Dodgers when they open a three-game road series against the Oakland Athletics on Friday night.
Colorado at San Diego 9:40 PM ET
Back in May, the San Diego Padres welcomed the Colorado Rockies to town after taking a weekend series from the Los Angeles Dodgers.
Philadelphia at Seattle 9:40 PM ET
Philadelphia Phillies right-hander Tyler Phillips is enjoying a storybook start to his career.