TORONTO -- Aaron Sanchez earned the win with seven strong innings and he was quick to give credit to his catcher, Russell Martin.

Martin threw out Jose Altuve trying to steal second base in the third inning and then hit a three-run home run in the sixth inning to lift the Toronto Blue Jays to a 4-2 victory over the Houston Astros on Saturday afternoon.

Josh Donaldson also homered as the Blue Jays (66-51) stopped a four-game winning streak by the Astros (61-56).

Sanchez (12-2) had to make some adjustments, going to offspeed more stuff after the Astros scored twice in the first inning. He allowed only those two runs, five hits and three walks while striking out six.

Houston starter Collin McHugh (7-10) allowed three runs, five hits and two walks while also striking out six in 5 1/3 innings.

"McHugh was on his game, my thinking was just to make pitches and give these guys a chance to win the game," Sanchez said. "Russ came up big on two plays, throwing out Altuve at second. I thought I gave him a good opportunity with a good time to the plate and he threw a strike. And then a few innings later, he came with that three-run bomb."

Roberto Osuna pitched around a two-out double by A.J. Reed in the ninth to earn his 26th save of the season. It was the 46th career save for the 21-year-old, matching Terry Forster's major league record for saves before a player's 22nd birthday.

"You've just got to keep guys like this off balance," McHugh said. "They've got a good lineup. There's really no give in that lineup."

The Astros scored twice in the first inning on a single by Alex Bregman, a double by Altuve and a two-run double by Carlos Correa, all to right field.

"We just had to make an adjustment out there, it seemed like they were just going to jump on the heater early in counts and they were getting some good swings off it," Martin said. "We kind of had to mix it up a little, throw some more breaking balls and offspeed and he (Sanchez) did that, threw some strikes with it and it kind of got them off the fastball just enough. Once he does that it takes away some of their aggressiveness."

Donaldson hit his 28th homer of the season in the bottom of the first.

The Astros had a run called back in the second after a video review showed that a ball hit by Tony Kemp down the third-base line was foul. It was initially ruled a double that would have scored Reed, who led off with a double. After Reed returned to second, Kemp grounded out to Sanchez and George Springer struck out to end the inning.

"Replay helps us more than it hurts us but that's where I wish they would have taken away replay for a day," Astros manager A.J. Hinch said.

McHugh retired eight batters in a row before Edwin Encarnacion singled with one out in the sixth. Michael Saunders took advantage of the shift and bunted toward third for a single.

After James Hoyt replaced McHugh, Troy Tulowitzki's groundout to third pushed the runners to second and third.

Martin hit his ninth homer of the season to center on a 3-2 slider to give Toronto a 4-2 lead.

"It felt good," Martin said. "I wasn't sure I got enough of it, but as soon as I saw him running back and it didn't look like he was going to catch it, that was good enough. And when it went over the fence it was even better."

"I felt like that was the right pitch to throw," Hoyt said. "I was confident in the pitch. Just maybe a little up."

"Russ had a huge day on a day when we needed it and Saunders laid down the bunt and that was big," Blue Jays manager John Gibbons said.

"The game turned on a dime with one swing," Hinch said. "Credit to him for getting a breaking ball 3-2 and hitting it out to the deepest part of the park."

Jandel Gustave took over for Houston in the bottom of the seventh and pitched around a single before pitching a perfect eighth.

Jason Grilli replaced Sanchez for the top of the eighth inning. He allowed a two-out triple to Altuve when Saunders tried to make a catch on the sinking drive in right field and let the ball scoot past him. Grilli finished the inning by striking out Correa.

NOTES: Houston OF Teoscar Hernandez started for the second straight game in center field Saturday after going 2-for-4 with a home run and a walk in his major league debut Friday. He became the fifth player in Astros' history to homer in his first major league game. His first hit in the majors was the home run. ... Astros OF Jake Marisnick (strained right groin) continued as day-to-day after being injured in the first game of Houston's doubleheader sweep of the Minnesota Twins on Thursday. ... Toronto 1B/DH Edwin Encarnacion became the 12th active player to reach 300 career homers Friday when he hit his 32nd of the season in the ninth inning. ... Astros RHP Mike Fiers (8-5, 4.46 ERA) will start the series finale Sunday against Blue Jays RHP Marcus Stroman (8-5, 4.76 ERA).