HOUSTON -- Right-hander Trevor Bauer worked six no-hit innings before departing with an elevated pitch count as the Cleveland Indians won the rubber match of their three-game series with the Houston Astros 5-1 on Thursday.

Astros shortstop Jed Lowrie spoiled the Indians' no-hit bid with a one-out solo home run to left-center field in the ninth inning off left-hander Nick Hagadone. Bauer, left-hander Kyle Crockett and righty Scott Atchison held the Astros hitless through eight innings.

Bauer (1-0) recorded a career-high 11 strikeouts but also walked five batters, a factor in his 111 pitches by the close of the sixth. Bauer had never thrown more than 119 pitches in 34 career starts and, given his inefficiency, the odds were minuscule that he could complete his start without working well beyond his previous threshold.

The Indians (2-1) provided Bauer a lead before he took the mound, with center fielder Michael Bourn stroking a leadoff double off right-hander Asher Wojciechowski in the top of the first inning. Bourn scored on a sacrifice fly from second baseman Jason Kipnis and Cleveland tacked on solo runs in the second, fourth and fifth innings.

Wojciechowski (0-1) pitched exceptionally during spring training, earning his first career start by posting a 1.29 ERA over six Grapefruit League appearances. His major league debut was rockier, with Indians catcher Yan Gomes scoring after his leadoff double in the second, catcher Roberto Perez hitting a two-out, solo homer to right field in the fourth, and shortstop Jose Ramirez adding a leadoff homer in the fifth.

Ramirez finished 2-for-4 with a walk, two runs scored and an RBI. He added a pair of stolen bases and scored on Carlos Santana's fielder's choice grounder in the seventh inning.

Astros designated hitter Evan Gattis became the first player in franchise history to strike out four times in consecutive games. He is 0-for-11 with eight strikeouts this season.

After striking out 13 times Wednesday night, the Astros fanned 16 times in the series finale. Houston has 36 strikeouts in three games.

NOTES: Astros RHP Asher Wojciechowski became the fourth Houston pitcher since the start of the 2014 season to make his major-league debut, joining RHP Nick Tropeano (Sept. 10, 2014, at Seattle), RHP Jake Buchanan (June 21, 2014, at Tampa Bay) and LHP Rudy Owens (May 23, 2014, at Seattle). He is the first Astros pitcher to make his debut at home since LHP Troy Patton on Aug. 25, 2007. ... Indians LF Michael Brantley was held out of the starting lineup for a second consecutive game due to lower-back soreness. Brantley will be examined on Friday morning after the Indians return to Cleveland, and his status for their home opener against the Detroit Tigers is in flux. ... Astros RHP Brad Peacock made his first injury rehab start on Thursday night for Triple-A Fresno against Las Vegas. Peacock, who had surgery on his right hip during the offseason, made one Grapefruit League appearance. He was placed on the 15-day disabled list on April 1 (backdated to March 30).