CHICAGO -- Left-hander Chris Sale made an impressive return from a foot fracture with a solid six-inning outing as Chicago White Sox beat the Minnesota Twins 6-2 on Sunday afternoon.

Sale, who was injured in February and didn't face any major league batters until Sunday, allowed just one earned run on six hits while striking out eight and walking one.

Designated hitter Adam LaRoche went 2-for-4 with a solo home run and two RBIs as the White Sox won their second straight.

Chicago also took two of three from Minnesota, its first series win of the year after opening the season with four consecutive losses.

Twins right-handed starter Phil Hughes (0-2) worked six innings, allowing three earned runs on eight hits, including a home run. He struck out four.

Four Chicago relievers combined to work the innings, limiting the Twins to one run on two hits while walking one and striking out one.

The White Sox gave Sale (1-0) a quick lead with two runs in the bottom of the first as LaRoche singled home left fielder Melky Cabrera. Shortstop Alexei Ramirez then drove LaRoche with his double to left.

The Twins got one run back in the third as shortstop Danny Santana one-out double scored left fielder Eduardo Nunez.

LaRoche led off the White Sox third with his second home run in two days to give Chicago a 3-1 lead. He launched a Hughes' first pitch to right field for his second homer of the season.

Minnesota scored once in the eighth off left-handed reliever Zach Duke. The Twins put runners on second and third with one out and right fielder Torii Hunter grounded third on a fielder's choice that scored second baseman Brian Dozier.

But Duke avoided any more damage when he got first baseman Trevor Plouffe to pop up while third baseman Eduardo Escobar grounded out.

The White Sox then added three eighth inning insurance runs off right-handed reliever Blaine Boyer.

Ramirez' one-out single to center scored right fielder Avisail Garcia from first. Normally light-hitting infielder Gordon Beckham then launched his first home run of the season to left, driving in Ramirez for a 6-2 lead.

The Twins have lost five of their first six heading into Monday's home opener at Target Field.

NOTES -- Paul Molitor returns home on Monday for the first time as Twins manager. He attended Cretin High School in St. Paul and the University of Minnesota before embarking on a 21-year Hall of Fame career that included his final three seasons with Minnesota. ... RHP Twins RF Torii Hunter is keeping a close eye on spring football and Notre Dame where his son, Torii Hunter Jr., is successfully juggling Irish baseball and football. He was top offensive newcomer for the football team last year. ... RHP Ricky Nolasco went on the 15-day disabled list with right elbow inflammation and RHP Trevor May was recalled from Triple-A Rochester to fill his spot. May will start Monday's home opener. ... Chicago has Monday off and then starts a five-day, six-day road trip with stops in Cleveland and Detroit. LHP Jose Quintana (0-0, 9.00 ERA) makes his second start of the season to open the series at Progressive Field. ... With Sunday's win, LHP Chris Sale improved to 7-1 all-time against the Twins. ... White Sox 1B Jose Abreu extended his on-base streak to six straight games, going 2-for-4 in Sunday's series finale.