BALTIMORE - Right-hander Jacob deGrom allowed one run over 7 2/3 innings, Curtis Granderson hit a pair of homers and the New York Mets took the series opener against the Baltimore Orioles with a 5-3 victory Tuesday.

New York also snapped the Orioles' four-game winning streak.

DeGrom (12-6), last season's National League Rookie of the Year, gave up five hits with one walk and six strikeouts. He has allowed seven runs in his past seven starts with the Mets winning each of those games.

Granderson passed first baseman Lucas Duda for the team lead in home runs with 22.

The Mets dominated most of the game and scored twice more in the ninth on a sacrifice fly by third baseman Daniel Murphy and on a wild pitch by Baltimore right-hander Brad Brach that proved to be crucial.

Jeurys Familia walked home a pair of runs in the ninth, but got third baseman Manny Machado to ground out to end the game, picking up his 33rd save.

Right fielder Gerardo Parra hit a solo homer in the sixth and now has four (13 overall) since being acquired by the Orioles from the Brewers on July 31.

Baltimore right-hander Kevin Gausman (2-5) had another effective start with little run support. He allowed three runs on six hits with a walk and six strikeouts over six innings on 109 pitches.

In his last outing, Gausman gave up three runs over seven innings with a career-high eight strikeouts against Seattle. However, he was outdueled by the Mariners' Hisashi Iwakuma, who threw his first career no-hitter.

Granderson gave the Mets a 1-0 lead when he belted his franchise-record seventh lead-off homer of the season over the right field scoreboard.

New York increased its lead to 2-0 in the third on an RBI double by Murphy. Orioles second baseman Jonathan Schoop appeared to have a play at the plate on shortstop Wilmer Flores, but bobbled the relay throw.

Granderson provided a 3-0 lead with another solo shot in the fifth - his third multi-homer game of the season.

Meanwhile. deGrom retired 11 straight batters before allowing a two-out double to shortstop J.J. Hardy in the fifth. Left fielder Henry Urrutia followed with a single to left but Michael Conforto threw Hardy out at the plate.

NOTES: C Matt Wieters was back in the Orioles' starting lineup after missing the previous five games with a right hamstring strain. ... The Mets promoted RHP Logan Verrett from Triple-A Las Vegas. He will work out of the bullpen. To make room, RHP Bobby Parnell was placed on the 15-day disabled list, retroactive to Aug. 17, with right shoulder tendinitis. ... Baltimore OF Steve Pearce (left oblique strain) took batting practice in Sarasota, Fla., and could be getting close to a rehab assignment.