TORONTO -- First baseman Edwin Encarnacion hit two home runs -- one into the 500 level -- to lead the Toronto Blue Jays to a 13-6 win over the Baltimore Orioles on Tuesday.

Right fielder Jose Bautista also homered for Toronto and second baseman Ryan Goins drove in three runs as left-hander Mark Buehrle picked up his third straight win to open the season.

Buehrle allowed eight hits, one walk and three runs in six innings to pick up his second win of the season against Baltimore.

Orioles right-hander Bud Norris (0-2) allowed six hits, three walks and nine runs in 2 1/3 innings. He was replaced in the third by left-hander Brian Matusz.

In two starts against Toronto this season, Norris has allowed 17 runs in 5 1/3 innings.

Encarnacion led off the Blue Jays sixth with his second homer of the game and his fourth of the season. It was the 18th home run to reach the 500 level at Rogers Center and the second hit by Encarnacion.

Right-hander Liam Hendriks replaced Buehrle and allowed an unearned run in the seventh. Second baseman Ryan Flaherty led off with a walk, took second on a single by shortstop Everth Cabrera and scored on a Goins throwing error on a grounder by designated hitter Chris Davis.

Left fielder Kevin Pillar ended the inning when his throw to second doubled up Davis after a diving catch on a sinking drive by center fielder Adam Jones.

Bautista hit his fourth homer of the season after third baseman Josh Donaldson doubled in the seventh.

It came after right-hander Jason Garcia threw behind Bautista that brought a warning from the umpires. Bautista directed some words at the Orioles dugout as he took his position in right field.

The Orioles scored two runs in the eighth, one on a groundout by third baseman Manny Machado and the other on a passed ball after Young singled and right fielder Travis Snider doubled.

NOTES: SS Jose Reyes (cracked rib, muscle strain on left side) returned to the Toronto lineup on Tuesday for the first time since leaving last Thursday after one at-bat. He said the rib bothers him only when he bats left-handed, so he will bat right-handed. ... Blue Jays 2B Devon Travis (bruised rib), who came out of Sunday's game after sliding back into first base on a pickoff attempt, was not in the lineup but could return Wednesday. ...Orioles SS J.J. Hardy (left shoulder strain), who opened the season on the disabled list, worked out Tuesday at Triple-A Norfolk, taking grounders and hitting off a tee, but he did not take live hitting. There is no timetable for his return. ... Orioles RHP Ubaldo Jimenez (1-0, 0.00 ERA) will Wednesday in the second of a three-game series against the Blue Jays, who will start rookie RHP Aaron Sanchez (0-2, 6.23 ERA).