Giants 5, Indians 1: Hunter Pence posted his fourth consecutive multiple-hit game and Michael Morse homered for the third time in the last two games as host San Francisco downed Cleveland in the opener of a three-game interleague series.

Pence, who is 9-for-16 over last four games, went 2-for-4 and drove home Angel Pagan twice while Brandon Crawford added an RBI single. Tim Hudson (3-1) allowed a run on four hits and issued his first two walks of the season over seven frames in his first start against Cleveland since 2004, marking the fifth time in as many outings the right-hander has worked at least seven innings.

Carlos Carrasco (0-3) fanned six over six innings, but yielded four runs on five hits to fall to 0-12 with an 8.09 ERA in his last 17 starts. Nick Swisher knocked in the Indians’ only run and joined Jason Kipnis with two hits apiece as Cleveland mustered only five hits.

San Francisco struck for a pair of runs in the opening frame as Pagan led off with a single and came around to score on Pence’s stand-up triple to right-center before Morse plated Pence three batters later with a sacrifice fly. Cleveland halved the deficit in the third inning when Michael Bourn tripled with one out and Swisher beat the Giants’ infield shift with a low liner into shallow left-center.

Pence got the run back in the bottom half with a hard-hit grounder into right and Morse made it 4-1 in the fourth as he hammered an 0-2 fastball for his sixth home run. The Giants padded their lead on two pitches in the seventh when Pablo Sandoval led off with a triple on the first offering he saw from reliever Josh Outman and Crawford ripped a liner past Swisher at first one pitch later.

GAME NOTEBOOK: San Francisco dropped its first five interleague games and finished 6-14 against American League opponents in 2013, tied for the worst mark in the majors. … Carrasco last won a start on June 29, 2011, five days after he notched one of his two career complete games in a loss to the Giants. … Hudson’s 6.33 ERA against Cleveland prior to Friday’s outing was his highest against any opponent he had started against more than once.