Astros 5, Red Sox 3 (10): Jake Marisnick's bloop ground-rule double in the top of the 10th drove in a pair of runs as Houston won at Fenway Park for the first time in franchise history.

Marisnick fisted a two-out fly ball down the right-field line off Junichi Tazawa after Craig Breslow (2-4) loaded the bases as the Astros snapped Boston's four-game winning streak and matched last year's total with their 51st win. Robbie Grossman had three hits and two RBIs and Tony Sipp (3-2) got the final four outs.

Yoenis Cespedes belted a two-run homer and Brock Holt had two hits and an RBI for the Red Sox, who fell to 8-1 all time versus Houston. Red Sox starter Clay Buchholz went seven innings, allowing two runs and striking out nine.

Cespedes followed David Ortiz's leadoff single in the fourth with a laser that cleared the wall in left for a 2-0 lead, but the Astros got a run back in the fifth on three straight two-out singles - the last by Grossman plating Marisnick. Grossman tied it in the seventh with another two-out hit - a blast to right field for his sixth homer.

Boston answered in the bottom of the inning on Holt's two-out single to right, but Houston tied it on a bizarre play in the eighth. Dexter Fowler beat shortstop Xander Bogaerts' flip to second on Matt Dominguez's infield single before Dustin Pedroia wheeled and threw home, but pinch runner Gregorio Petit eluded catcher Christian Vasquez in a rundown and leaped over pitcher Burke Badenhop's attempted tag at the plate.

GAME NOTEBOOK: Astros LHP Dallas Keuchel went seven innings, permitting three runs and fanning eight. ... Cespedes' homer, his first at Fenway, was his third in five games and gave him at least 20 in each of his first three seasons. ... Pedroia was replaced by 2B Kelly Johnson in the field in the top of the ninth inning.