Ramirez missed the series-opening 7-3 win with a bruised right wrist after being hit by a pitch in Thursday's game against the New York Yankees. He returned and batted third Saturday, going 2-for-5 with a strikeout.

Andrew Benintendi also had three RBIs, and J.D. Martinez hit a solo homer and drove in two runs total for Boston. The Red Sox continued their offensive onslaught with a seventh straight game with six or more runs for its 12th victory in 13 attempts.

Cobb (0-1), a Massachusetts native who spent his first six major league seasons with Tampa Bay before signing with Baltimore, struggled mightily in a park in which he has fared well historically. He allowed eight runs (seven earned) on 10 hits -- including two homers -- and a walk in 3 2/3 innings.

The right-hander was 5-1 with a 3.15 ERA in seven starts at Fenway Park before Saturday.

Pedro Alvarez drove in a pair of runs and Chance Sicso added an RBI for Baltimore, which suffered its fifth loss in seven games.

Boston starter Hector Velazquez (2-0) earned the victory with five innings of two-run ball, giving up six hits and walking one while striking out five.

The Red Sox lost All-Star right fielder Mookie Betts to a foot injury in the first inning during a collision at home plate. Betts was diagnosed with a left foot contusion, and his X-rays came back negative.

Boston scored three runs in the first, one in the third and four in the fourth to build a 8-0 lead before Baltimore scored twice in the fifth. Single runs in the sixth and seventh for the Red Sox put any hopes of an Orioles comeback to rest.

Boston ace left-hander Chris Sale (1-0, 1.06 ERA) opposes Baltimore right-hander Dylan Bundy (0-1, 1.35 ERA) in the third game of the weekend series Sunday afternoon.

--Field Level Media