Josh Jacobs rushed for 106 yards and three touchdowns and the defense forced three turnovers to lift the host Green Bay Packers to a 38-10 rout of the slumping San Francisco 49ers on Sunday.

Green Bay (8-3) avenged last season's playoff defeat to the reigning NFC champion 49ers, who lost their second game in a row to fall to 5-6.

Jordan Love passed for 163 yards and two touchdowns, helping the Packers to a season high in points.

Green Bay scored the first 17 points, moving the ball efficiently against a San Francisco defense whose inactives included defensive end Joey Bosa (hip, oblique) and cornerback Charvarius Ward (personal matter).

Injuries on offense also took a toll. Brandon Allen started at quarterback for San Francisco in place of Brock Purdy, who was out with a sore right (throwing) shoulder, while left tackle Trent Williams also missed the game.

Love hit Tucker Kraft for an 11-yard touchdown pass on the opening drive. The Packers made it 10-0 on Brandon McManus' 51-yard field goal late in the first quarter and surged ahead 17-0 on Jacobs' 1-yard TD run with 6:33 left in the second.

Jacobs struck again with 4:28 remaining in the third quarter on another score from a yard out. Green Bay capitalized on a short field after Xavier McKinney intercepted Allen and returned the ball to the San Francisco 26.

Following a Jake Moody field goal for the 49ers, the Packers scored another touchdown off a takeaway. Jacobs sealed the third three-TD effort of his career with 10:59 left in the game, shortly after Allen fumbled on Lukas Van Ness' sack and Kenny Clark recovered at the Niners' 16.

The 49ers punted on their first two possessions but the attack began clicking before halftime. San Francisco collected its initial first down on an Allen pass to fullback Kyle Juszczyk, which proved to be the first play of a 11-play, 65-yard touchdown drive. Allen capped the possession with a 3-yard scoring pass to George Kittle.

Green Bay racked up a 218-95 edge in total yards in the first half.

Allen was 17-for-29 passing for 199 yards with a touchdown and an interception. Christian McCaffrey gained 31 yards on 11 carries while Kittle had six catches for 82 yards and a TD.

Romeo Doubs led Green Bay with three catches for 54 yards.

--Field Level Media